Top Definition
When members of a large cult or religious group commit mass suicide. When people whom the world, and the gene pool could really do without, decide to take their own lives in mass quantity.
1.Cult leader Jim Jones asked 914 of his followers to join him in natural self selection by drinking the fruit punch.

2. I wish everyone on E! t.v. would finally give into natural self selection.
by The Socket Rientist January 27, 2011

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