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1.
When you just frikkin' do it! Or when you get after it. To do something with gusto at 110%. You can nail just about any activity.
Food Example:
Bob: Dude I'm hungry; I could totally go for some pizza.
Carl: Nail it man! Just friggin' nail it!

Alcohol Example:
Bob: I just nailed that beer... get me another one

Gambling Example:
Bob: <At the craps table just before the throw or after a win> NAIL IT!!!!! NAIL IT!!!!!
by Jethro Tull August 06, 2008