A strong disagreement. "No!"
-That girl is pretty.
-Na yo, that wench is a hoodrat!
by Sony August 10, 2003
Exression of dissapproval. Replacement for no. Started from the disgust in Nayonaise, a soy based mayonaise alternative.
Nayo on the mayo, that stuff is gross.

"You want to come by and watch the OC?"
"Nayo!"
by liz March 10, 2005

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