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1.
An "indie" fashion/art/music magazine that is primarily targeted towards girls in their late teens and twenties. NYLON was created in 1999 by Marvin Scott Jarrett, who "never set out for NYLON to be the biggest magazine - just the coolest." It frequently features "It Girls" like Cory Kennedy and Peaches Geldof, and lesser-known (but still relatively popular) actresses and bands such as Lily Allen and Camilla Belle.

Contrary to popular belief, NYLON is not only read by "hipsters" and "indie kids," although they certainly make up a large percentage of the "letters to the editors."

Although it can sometimes be overbearingly pretentious and preoccupied with being unique, NYLON provides a nice alternative to the mass-produced "Seventeen" and "Cosmo" magazines that are so popular today. As long as you don't buy into every word of every article, NYLON can be an enjoyable magazine that introduces you to new ways of dressing, up-and-coming bands, and more.
NYLON letter to the editor from a dedicated fan: "dear nylon, you are my bible. you are the mozerella to my maccaronni, the ranch to my green salad. you are a stellar piece of work & just fabulous. you are the love child of art, fashion, music, and sex. i literally scream every time i see you in the mailbox, because that is how much i love you. marry me? xx"

casual NYLON reader: "Yeah, NYLON is pretty cool. I loved how they featured Lily Allen, she makes really catchy music, but she's not nearly as overrated as Miley Cyrus or PCD. And their fashion layouts gave me some awesome ideas for new outfits! That one article by that 'It Girl' was way over the top, though. She made it sound like every girl who listens to mainstream music every once in a while is some kind of blood traitor. It was so 'holier-than-thou!'"
by buffytheglitterslayer July 02, 2009
 
2.
women's stockings made from a sheer material (nylon or rayon or silk)
Mike wore some sexy nylons to the drag show
by Bigger Red October 22, 2011
 
3.
Colorful nickname for the city of New Orleans, Louisiana, as pronounced in the distinctive New Orleans patois
Guy #1: I'm going to be taking a trip down to Nylons later this month.
Guy #2: I believe most people call it Nawlins.
Mayor of New Orleans: Both pronunciations are acceptable.
by globochem July 12, 2010
 
4.
From New York and LONdon - a trans-Atlantic commuter, usually in financial services, consulting, fashion, or media. A subspecies of yuppie with lots of frequent-flier miles and a tri-band cell phone.
Ken has been a nylon for about six months now - he's really racking up the miles. And the best part is, when he plays hooky, everyone thinks he's in the other office.
by Sendhil February 16, 2005
 
5.
A small or big growth on your hand that never seems to go away.
A wart which is called a nylon
by Sam and Jessica March 05, 2009