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Mutating is synonymous with a day of laziness. To mutate is to chill or relax. Be mushy.
I'm sorry I can't run with you this afternoon, I'm planning to lay around and mutate
by DarleneOliviaPope June 10, 2017
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2
To exert ones limit of intoxication.
"Fuck, I don't think I can handle another hit, I'm about to mutate"

"Man, we're gonna fucking mutate, Ive already had a bottle of vod, 11million joints & 32 pills, shit!"

"FUCK MAN, I'VE MUTATED"
by YoBitchorsomeshitlikethat September 28, 2009
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