Top Definition
When someone dresses and looks like dubstep artist Skrillex. Wearing his trademark thick rimmed glasses and shaving only half their head.
"I went to the mall last week and it looked like every other teenager came down with a bad case of Multiple Skrillrosis."

"Is that Skrillex? No its my sister, she has Multiple Skrillrosis."
by GrazIsSoCool June 26, 2012

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