Top Definition
A hilarious late night comedy show that aired on HBO in the mid-90s. The show's style could be described as "satirical comedy for Generation X...with Abe Lincoln jokes." It was a launching pad for the careers of David Cross, Bob Odenkirk, Sarah Silverman, Brian Posehn, that gap-toothed guy from Best Week Ever that isn't Paul Scheer, and the greatest comic to ever live: John Ennis.

Plus, in this writer's experience, chicks dig Mr. Show more than chocolate and romance novels.
Frat Guy: Hey, did you see Mr. Show last night?
Sorority Chick: Did I?! That John Ennis made me laugh so hard I peed my pants!
Frat Guy: He's our generation's Tom Arnold alright! Do you wanna go to the bathroom and make some tongue children?
Cue fellatio
by Parkinsons August 13, 2008
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