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1.
Much alike the word mofo. Actually, the meaning is the same really. A shortened, funner term for mother fucker. Common in SO CO, STL
I can't believe that Mother Fo said that.
by Ashly December 11, 2003
 
2.
A derivative of mofo. Also known as mofucker.
1: "d00d, hand me a slice o' pizza"
2: "step off, muthafo!!"

See mofo, mofucker
by CMack February 26, 2005