Top Definition
Also known as MLS. An act committed, so devastating that it single-handedly manages to become the definition of your character, no matter the greatness you had achieved up to that point or will achieve in the future.

Famous Victims:
Bill Clinton
R. Kelly
Tiger Woods
After Jeff punched that sorority chick in the face, his Monica Lewinsky Syndrome diminished his friend count both in RL and on facebook. All this occurred despite his ability to acquire "mad" kegs.

Randy's MLS left him forever: "the guy whole stole all that money from the church collections." Devaluing all the great work he had done up to this point.
by AllAbouttheLaptops March 28, 2010
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