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1.
When someone is so astounded, they can't even form a comprehensive sentence. First used by Chuggaaconroy, a famous Youtuber in one of his Pokemon Crystal episodes, it quickly reached meme status.
Friend one: I just caught a rare pokemon that you don't have
Friend two: Mind = blown
by The Altruistic Anomaly July 09, 2011
 
2.
The act of hearing, seeing, feeling, smelling and tasting something so amazing, your mind will be blown away. Primarily shown as images to show the greatness of mind=blown.

Used mostly in internet message boards and chats when an individual shares an post/message of something deemed as mind blowing. Can also be used as a term for sarcasm when posting/chating to make an individual the butt of a joke.
examples of mind= blown include:

- chuck norris,

- most interesting man in the world

- pi 3.14 41.3 mind=blown
by Dzlulz December 27, 2011