The town in which the movie Donnie Darko took place.
Other guy: Hey Donnie, what school do you go to?
Donnie: Middlesex High School
by Radomsooner March 03, 2010
Town that is full of tough guys. They act tough to everyone and nothing scares them. They are all hardasses and don't give a damn. They are known for their whiteouts and sick chants and the roller coaster at halftime. They will put any other fans to shame asbling as the situation presents itself. This us all with the help of the loudest man alive who currently lives there.
Middlesex: If you're winning and you know it clap your hands!


by Anonymous4e March 12, 2009
Mediocre or unremarkable sex.
Bill: Was the other night good?
John: Eh, it wasn't good or bad, it was just middlesex.
by frenchdinnerparty April 11, 2007

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