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In the center of a large area with no notable economic, social, geographic, cultural, or other values. The "Fucking" aspect of the phrase is usually associated with the frustration that comes with being located in the "Nowhere" that is being referred to.
"Jesus fucking scrotum-christ, where's the map?! We're in the middle of fucking nowhere!!!"
by tormentorofsouls666 March 26, 2010