Top Definition
A time of mental breakdown that occurs during a person's twenties, often a result of an inability to function outside of college/university or other types of structured environments. Feeling alone and/or useless also tends to be a symptom of the mid-twenties breakdown.
Soon after Paul finished grad school at age 24 he found that he couldn't get a job and had a mid-twenties breakdown and moved back to his parents' basement where he spent most of his days playing Xbox and smoking weed.
by Johnny Z. Styles May 28, 2010

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