Top Definition
the physical launch of one's being into orbit after having a very scrumdiddlyumpcious dinner of one home made south of the border burrito with nothing excluded. One to have a Mexican takeoff can be recognized by a brown smudge on white pants.
Charlie "Man, that burrito was delicious, but it took a toll on my stomach."

Will "dude why does it sound like an engine is running?"

Charlie "Oh god, I can't hold it!"

-eruption occurs-

Will "Looks like he had a Mexican Takeoff."
by Unholy Bojangles April 26, 2010

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