Top Definition
Horrible diarrhea, usually measured in days or weeks. See also: Two-Day Mexican Road Trip.
1. I'm not sure what I ate on Friday, but I've been on a Two-Day Mexican Road Trip since.

2. I enjoyed lunch - thank you so much. Now, if you will excuse me, I must begin my Mexican Road Trip.
by Robthegod May 07, 2010

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The Urban Dictionary Mug

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