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1.
The first Japanese female Vocaloid, and essentially the first Vocaloid Meiko was created by Crypton Future Media. She has a very strong voice, and does not(and really shouldn't) sound "cute", so when Hatsune Miku was released, her popularity went down, and it just kept on getting worse and worse. Eventually, there was even a fanmade version called "Sakine Meiko" to try and get her popularity back!

Anyway, Meiko honestly has some of the best Vocaloid songs I've heard(Snow Rabbit/Yuki Usagi, Accordion in the Golden Sunset, Far Side of The Sky, ect. By the way, these are all subbed.) so if you've never heard of her, you should check her out.
Dude One: Have you ever heard of Hatsune Miku? She's amazing!
Dude Two: Yeah, but I like Meiko more. She was released first and I like her voice more.
Dude One: ...Alright, then.
by 9001-mudkipz October 25, 2011
 
2.
A very charming person who has a lot going for themselves but doesn't see the potential that they have. very kind and caring but can be very mean when they feel crossed and betrayed. usually good looking and if not he/she makes up for it with their fun loving personality. once you meet a meiko you can never just forget about them like they were never in your life, they make a huge impact on you whether you want them to or not.
What a meiko he is.
by TheGodOfWizdom February 11, 2013
 
3.
A Puerto Rican femminist who has no arms and will do anything for food and sex.
That kid is being a real Meiko.

Oh look! It looks just like a Meiko!
by OmgShoes January 16, 2007