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1.
To hold a shit in for 24 hours after it originally wants to come out. The resulting pleasure from clenching your cheeks for a day before releasing makes it so much better.
Thompson really needed to do a poo poo but realised that if he megaplexed he would thank himself later
by Hman November 12, 2006
 
2.
A plethora of mental/emotional problems.
I gave up dating Caucasian women in favor of foriegn-born Asians, American women all have a megaplex.
by nilpferd August 11, 2003