MDS
Major Down Syndrome, when some one is very retarded.
My good friend raged on xbox live and punched his mum... something only someone with MDS would do...
by AzFLYINGzFRIDGE April 20, 2011
Mds
Masterbation Depervation Syndrom. The male form of pms, occurs when males fail to masterbate frequently enough inturn making them have all the bitchy qualities of a girl on her period.
Fran: "Dude, Jim is being a total bitch lately!"
Nicole: "Yeah he's totally mds-ing, gross..."
by Sick of bitchy boys December 20, 2010
MDS
not seeing a person for a certain length of time; missing seeing that person just because they're awesome
I was getting the MDS when I didn't see the Magster for awhile.
by C'mon man! April 07, 2010
mds
Portuguese shorthand for Meu Deus, which translates in English to My God! Often used online
Person 1: Foi pra pria hoje e eu estive roubado... (I went to the beach today and I was robbed)
Person 2: Mds, que horrivél! (My god, how horrible!)
by HiVoltage December 14, 2014
MDS
Million Dollar Shit
of the same origins of MDP, you feel like you would have paid a million dollars to take that shit if you knew how much better you would have felt. usually occurs on trips, or other times when a bathroom is not readily available.
Zach: wow you look a little too happy coming out of that bathroom
CJ: dude MDS straight up.
by ZAOS November 18, 2009
MDS
N. Micro Dick Syndrome
1. Connor F. is on the verge of MDS

2. Hey, how's MDS therapy been? I'm a survivor myself.
by ChillChill May 16, 2011
mds
short for Manu Down Syndrome; A sexually transmitted disease (STD) that can only occur when intercourse has been achived with Manu Jordan. Effects are blahblahblah..
Ohh man.. George caught MDS and now we can barely understand him.
by BillaBobb April 22, 2009

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