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2.
Where you subconsciously start disliking something just because loads of people tell you that its great.
I finally watched that Slumdog Millionaire film last night, everyone was telling me it was the greatest film ever

Did you like it?

No, it was fucking shit!

Really? Sounds like you have got McDonald's Syndrome to me
by SamThe Man April 09, 2011
 
1.
The disease of constantly spilling soday, on the ground your self, other people or just in general.
Kris -spills coke-
Sierra: WTF
Kris: Geeze sorry I have Mcdonalds Syndrome.
by sierrasurvey May 03, 2008