An instinctive and unfounded hatred of any replacement, sequel etc. which fails to fill the immense shoes of its predecessor.
Guy 1: "Shit, how bad were Pirates 2 and The Matrix Reloaded?"
Guy 2: "Ah cmon, they both had their merits"
Guy 1: "Nah, completely sucked ass, with no redeeming features"
Guy 2: "Think you're suffering from Matrix Syndrome dude"
Guy 1: "This new boss is a real douche; he's got nothing on our old boss!"
Guy 2: "He's been here one day. I reckon you've got Matrix Syndrome"