Top Definition
An overwhelming disease (of the mind) that makes one's body feel as if they are unable to operate before 3:00pm EST, and unable to take part in activity, such as work.

After 3:00pm EST, all bodily function are operating normally, along with a rejuvenated sense of joy and mirth.

Winters in London are very accommodating to the disease.
Mastrandritis can be exhibited in the attitudes and actions of lazy employees that lie.
by DrFa April 27, 2011

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