Top definition
The irrational worship of an NFL player named Manning. Where if Manning did not exist there would be zero allegiance to anything football. If one names their child Peyton after this undeserving object of praise it should be followed by immediate therapy and, if proven ineffective, incarceration.
John: The Indiana Colts are going to beat the hell out of the Jets.

Lindsay: It's Indianapolis Colts and aren't you from Chattanooga, TN.

John: Yeah, what of it. I gotta go pick up Peytonette from school, bye.

Lindsay: John, you should ask your doctor about Manningism. You're a friend of mine and I'm beginning to worry about you, your wife, and little Peytonette.
by Jimmy D'A January 08, 2011
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