A man who has such terrible hair that he resembles the mythological beast known as Medusa.
Example 1:

Random dude at a party: Hey, bro. Killer hat! Can I try it on?

Me: Fuck no! I don't want my hat anywhere near that mandusa.

Example 2:

Dude 1: I think I need a haircut.

Dude 2: Ha! There's not a barber in town that can slay mandusa!
by Tandoori Boner August 19, 2010

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