look up any word, like cleveland steamer:
 
6.
Out of all the people you could be chilling with they're the one you always with. Number one on your list, they're might be others but that's the one you always roll with.
"I can't go out tonight I'm gonna try and chill with my main squeeze. "
by Msgreenthumb November 08, 2013
 
1.
its the most inportant of your many girlfriends or boyfriends, its the you like the most
man i like sarah and rachael but becca has to be my main squeeze
by rmawills October 15, 2003
 
2.
The person who you have your primary romantic/sexual relationship with, although you also see others casually.
I spent Friday night with my main squeeze after seeing that chick I sometimes mess around with in the afternoon.
by PolyGirlie October 14, 2003
 
3.
One's boyfriend, girlfriend or spouse.

This humorous phrase dates back to the 1800s, when it referred to a powerful or important person. In the 1970s, it began to refer to romantic partners.
1) I'd like you to meet Holly, my main squeeze.

2) The story is about a young man and his main squeeze, a cute coed named Nancy.
by VAKI5 May 11, 2005
 
4.
The girl/woman you'll always have strong,intimate feelings for. No matter what. The person that gives you unimaginable drive to do whatever you set your mind to. Who makes you unbelievably happy and makes your butterflies' butterflies' have butterflies. The person who you have no problem completely opening up to. A person who's your girlfriend and your bestfriend; who you can tease and get made fun of back and it's completely and "toats" "k". It's a person who instead of saying you automatically felt a spark/connection with, you say you felt fireworks. It's simply that one and only ultimate other-half. That one person, that you know, has changed your life for the better. "Simply Because..."
Randy: Man.
Dominic: What?
Randy: Jasleen Bain's is my Main-Squeeze. Without a doubt.
Dominic: Yeah, I can tell.
Randy:It's no secret. I'm proud to say it. To everyone.
by DINGLEBERRY ;] October 17, 2010
 
5.
Like a boyfriend.
Or used also as a term for friends.
"Aye though do you got a mainsqueeze?"
"I'ma kick it with my mainsqueezes later."
by ohwowsapalooza April 16, 2007
 
7.
A word commonly used in substitute for girlfriend, or lover.
"sorry dude, i cant go clubin' tonight, im chillin' with the Main Squeeze."
by Kenny Koston September 28, 2011