Top Definition
A condition named after an American female pop icon who suddenly developed a British accent after living in England for a few months. Symptoms lessen over time but may persist for years. In addition to the fake accent, symptoms may include referring to "soccer" as " "football"; failing to tip in restaurants and saying "cheers" instead of "thanks" long after the accent has disappeared.
"I was watching Johnny Depp on Letterman the other night and I could have swore he was speaking with a British accent, is he from England?"

"No, he's American, he's from Kentucky."

"Ahh, he must have Madonna syndrome."
by jpc1 August 06, 2009
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