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1.
A sci-fi and gaming convention that has been running on the campus of JMU for over 20 years.
"Hey, did you see all the nerds on campus?" "Yeah, it's that Madicon thing again."
by JMUNerd February 22, 2012
 
2.
A bastardized Spanish version of mother-fucker
Besa me coolo, madicon! (Kiss my ass, mother-fucker!)
by miaham July 25, 2008