It's possible to win when you should lose, but it's harder. Maddenitis usually happens when the two players are around even skill level.
Person 1 starts off with the "upper hand" and plays with ease. This would mean that Player 2 has maddenitis, and next match, Player 1 will have it.
"Wow, the only reason you picked that was because of Maddenitis."
1. your hands are hurting excessivly because of overplaying.
2. you withdrawl from all your friends to play the game in your dark basement alone.
"Hey, how about you call Chad to see if he wants to come to the movies with us?"
"Nah, he's got Maddenitis."