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Originates from Goole in East Yorkshire, meaning Huge, Massive!
Ooo i cud eat a mackoff peice of cake right now!
by Kerry November 09, 2004
Huge, enormous.
Girl: Shit! There's a Mackoff spider in the shower!
Boy: Calm down, it's not that big.
by Squiggles2011 March 25, 2011