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2.
An exorbitantly over-priced shit hole of a restaurant located on the corner of 4th and Pine St. in Jamestown NY. Owned by a pompous, senile, and downright unpleasant crazed man affected by severe PTSD, MacDuff's is infamous for catering to approximately 50 gullible, senile, and rich old people annually, as well as being one of the greater rip-offs in the western hemisphere. No one likes the place, except those whose brains have become victim to severe atrophy and are lured into the establishment by the aforementioned owner's domineering demeanor. MacDuff's is one of those places that would be better off not existing, along with the assface of an owner.
Hey, what smells like rotten fish, death, cold cream, and napalm???

Oh, it's only MacDuff's. You get used to it after a while.
by 3rd St. Cowboy May 24, 2010
 
1.
One of the most important characters in William Shakespeare's Macbeth. In the play, he is the Thane of Fife, starting off as an incredibly minor character. However, after Macbeth becomes king of Scotland, he orders Macduff's family to be killed, Macduff swears revenge. It was prophecized that Macbeth could nto be killed by one born of woman, but Macduff's mother had a Caeserian Section, so he techinically wasn't born, he was taken out. Macduff decapitates the tyrant and holds his head aloft for all to see.
"Know thee Macduff was from his mother's womb untimely ripped!"
by Hydragon August 11, 2005
 
3.
A shitty fishing port on the Moray coast in Scotland populated by smackheads and psychos, mostly.
I'd rather eat my own tampons than live in Macduff.
by EmpressOfBlandings September 05, 2005