When a gym and fitness enthusiast wants to take their workout to the next level yet does not want to go to BEASTMODE, lift heavy weights, but get intense on the stepmill or treadmill to build a lean and tight body.
Bikini competitor- "I'm off to the gym! #MACHINEMODE and burn 600 calories!"
When a male goes to a social gathering (such as a bar or club) and tries to chat up every female at said gathering.
A male in machine mode who gets knocked back by a female, will quickly forget about the female and move on to another female, often the nearest female to the first female and probably the first female's friend.
Friend 1 @ a club: "Alright mate, where you been for the last hour?"
Friend 2 @ the club: "No time to chat, I'm in machine mode tonight, I've already been knocked back by half the girls here... time to move on to the fat chicks. Later."