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1.
The "Louis Vuitton Don" is a nickname of Kanye West.

In the song Last Call, from his first album College Dropout (2004), Kanye West refers to himself as "Kan, the Louis Vuitton Don".

In Janet Jackson's song My Baby (2004), which features Kanye, he again refers to himself as "Kan, the Louis Vuitton Don".

Kanye West has since been referred to as the Louis Vuitton don many times in songs, media and popular culture. In 2009, Kanye West and Louis Vuitton released a range of mens shoes named the "Louis Vuitton Don".
Kanye West - Stronger: "This is Louis Vuitton Don night. So we gonna do everything that Kan like."

Kanye West - Last Call: "I'm Kan, the Louis Vuitton Don. Bought my mom a purse, now she Louis Vuitton Mom."

Janet Jackson - My Baby: "You see I go by the name of Kan the Louis Vuitton Don. I'm with my home girl..."

Pharrell - Number One: "Your now listening to, Skateboard P and the Louis Vuitton Don"

Kanye West - Celebration: "the Louis Vuitton Don is signing off"

Big Pokey - You Can Hate: "Its Graduation time and no disrespect to Kan (what it is Kanye), but tonight I'm the Louis Vuitton Don"
by Don Trapstar October 04, 2011
 
2.
An expression used in the Kayne West song "Stronger." Could alternatively refer to A) a time when it is appropriate to wear Louis Vuitton stuff and therefore become excited and unininhibited or B) A patriarchial pimp-daddy figure who is associated with Louis Vuitton.
I'm caught up in the moment right? Coz it's Louis Vuitton don night...
by kupokupo October 28, 2007
 
3.
Kanye West is the Louis Vuitton Don because he wears Luis Vuitton and he tell every body to call him the louis vuitton don because he is a playyaaa!!!!
Person1: hey theres Kanye
Kanye: I am not Kanye Im the louis vuitton don. just look at my clothes. fifty doesnt rock this shit he is all like "im from G-unit n***as, talk shit all bust a cap in your ass, im the best rapper to ever live even though Ye sold more records then I did. POP POP SKIT SKIT N***a."

IM THE MOTHER FUCKING louis vuitton don

(CHI Town represent)
by J WISE November 15, 2007