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To lose ones mind.
Emily: "Nigga you crazy, I'ma lose ma skittles on the bitch"

Erik: "The psycho was all up in ma grill. I put the shot glass down and I almost lost my skittles on the kid."

Geneva: "Keep it cool, you don't wanna be goin' around, losing your skittles on people, popo might got somethin' to say about that!"
by Neofishfries May 01, 2011