A bastardization of the term "User Friendly". Used to describe software that has been engineered to be compatible with the dumbest beings that a civilization has to offer.
Microsoft Windows is very loser friendly.
A term for a business establishment that allows people to smoke inside, like a bar in a state where that is still legal. This could also be a hotel that still has smoking rooms or a gas station or stop-and-rob mini mart where losers are allowed to light up. A loser friendly establishment smells like cigarettes, so normal people will not want to be in there.
That store is loser friendly, so let's go someplace else.