1.) When the ammunition container is filled.
2.) Rigged or fixed for cheating. Usually describes a pair of dice.
3.) Being in the state of Drunkenness.
4.) In the state of being high.
5.) Having a lot of money.
2.) Hey, those dice are loaded!
3.) Oh man, Shelly is so loaded right now.
4.) See above.
5.) Look at all this loot. The owners must be loaded!