Top Definition
It is a condition where a small or short man will be generally more agressive towards tall or larger men.

The person with Little Man's Disease is trying to make himself seem stronger or better than the bigger person and is generally hostile or moody towards them.
'That geezer over there must have little man's disease. Look at him trying to start a fight with them to massive guys'.
by Oliver Vantini August 05, 2008

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