A syndrome commonly seen by prostitutes, whereby the John is unable to get arroused. If the prostitute is a high end well experience sex trade worker she will easily be able to isolate the psychological barriers preventing the John from attaining an errection and completing the service. However some prositutes may be forced into prostitution on the black market and are not experienced or highly intuitive and this may in some cases perpetuate little john syndrome indefinitely.
Anise experiences little john syndrome on a regular basis and soothes the John by feigning innocence to the johns issues at the john (aka crapper/pisser) and John's guilt and self-loathing for visiting her instead working and going home to his wife.

Lacuna experienced little john syndrome for the first time after Stanko brought her John into the motel room. When the John saw the disgust and fear in her eyes it served to perpetuate his little John syndrome.
by p@$$ing thr.ugh December 22, 2010
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