This term derives from the character of Liquid Snake as seen in the Metal Gear Solid franchise. It can refer to a number of things, especially a combination thereof:

1). A person, character, or thing which will not die, no matter how much damage is done to him/her/it.
2). A person or character who speaks with a ridiculously pronounced or obviously fake British accent.
3). A fairly long-haired blonde guy wearing no shirt in a very cold environment.
4). A character who gives way too much self-exposition, especially a villain.
5). A person or character with an illogical inferiority complex.
1). Jim fell 50 feet and got off with just bruises! The guy has some serious Liquid Snake Syndrome going, I swear.
2). John, quit trying to talk like that. You don't sound cool, you've just got Liquid Snake Syndrome.
3). (Upon seeing a blonde football fan in the stands with his shirt off and chest painted) Talk about Liquid Snake Syndrome! It's December, for Pete's sake!
4). (Watching a TV show or a movie where the big bad guy won't shut up) Will this dork get over his Liquid Snake Syndrome and fight already!
5). Chris, just because your boss went to Harvard doesn't mean he's smarter than you. Lose the Liquid Snake Syndrome and stand up for yourself!
by Rambaldi47 December 04, 2007

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