A person (usually female) that hs been subjected to lots of plastic surgery, liposuction, collagen injections, etc. 'Lipo' comes from the word 'liposuction'. 'Lizard' comes from the skin being very tight around the jaw and neckline, thus making the face look reptillian in nature. Also emphasis on over-inflated lips from collagen injections, adding to the reptillian (or amphibian) effect. Breast implants can also factor in the defintion.
"Hanging out at Nordstrom's, we saw some lipo-lizard, she looked like she had at least 20k worth of surgery done on her face....."