Top Definition
a girl or woman who cannot get a date no matter how hard she tries. Many of these individuals are nice, clean, caring people who just don't have the looks, money or popularity to find a partner.
Nancy is a pediatric nurse who makes $25 an hour, but cannot find a date. But while she is a kind, caring, talented, giving person who anyone would be happy to know, she is also 5'2 and 300 lbs, rendering her a Leftover Lisa, as men generally do not see past her size.
by Laiho's Eyeliner August 04, 2008

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