What you call someone when they constantly wash their hands.
Kayleigh - *Washes hands for 50th time in 4 hours*
Me - "Woah! Lady Macbeth, get out the sink!"
by Rob Mulder April 23, 2006
An unpleasant, cruel, or maliciously insane woman. The female incarnation of Evil Itself.

Often used to refer to female math teachers.

Taken from the the unpleasant character in Shakespeare's Macbeth.
Student: Who do you have for math next semester?
Friend: Mrs. Whitman, you?
Student: Roberts. Wait--Did you say Whitman?
Friend: Yeah, why?
Student: Watch out, man. She's like freaking Lady Macbeth.
by Lady Chevalier May 11, 2005
when you get someone's cum on your hands and no matter how much you wash you just can't seem to get that damn smell out
Ugh, I have a total Lady Macbeth going on after that hookup, even though I showered twice!
by doorfish July 01, 2010
Literature's biggest douche. The bitch is fucking crazy.
Lady Macbeth is fucking crazy.
by Harley Austin January 18, 2012

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