Top Definition
A branch off of the abbreviation of "Laughing My Fucking Ass Off", but at a higher level of meaning than LMFAO.

Wow I just watched George Lopez and all I gotta say is LMFIASCO.

Me: Me and propaYne beat Nate on Halo 50-4
Friend: LMFIASCO... thats Rape
by Rhymestyle June 25, 2008
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