Top Definition
V. The act of female masturbation so frequent and furious that one's knuckles become raw from constant friction and moisture.
"While my partner was away for the summer, I spent my days and nights totally knuckle-dusting the shit out of myself".

"The pain of knuckle-dusting is nothing compared to the pain of loneliness and celibacy".

"Knuckle-dusting is the chain-smoking of sex".
by PenePee December 05, 2013

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When a loved one or significant other won't help a bro out and he's forced to knuckle his own junk. Said bro shoots baby batter into his own hand and allows it to dry. The following morning punches the unwillingly participant from the night before creating an eruption of cum dust shooting from his knuckles.
Liz wouldn't go down on mike, so he gave her a full-on knuckledusting the next morning.
by Georgiamrlory July 19, 2010

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The act of putting dust or some form of powder on ones fist then proceeding to punch someone or something with enough force to wipe the dust from their knuckles.
Knuckle Dusting

Person A: Yo I heard you knocked out that annoying guy at the gym.

Person B: Yeah, I powered up my hands and knuckle dusted that fuckboy.
by SoHCypher February 17, 2017

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