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1.
1. A female about to experience the knuckles of another human in her face.

2. A female so ugly it appears as if she was repeatedly set in a corner and fed knuckles to her face by her parents.

3. A reference by African American women of other African American women, usually a friend.
1. That woman makes me so mad. Ima about to make her into a knuckle hoe!

2. Oh man! Look at that ugly a$$ knuckle hoe.

3. Ima call up my knuckle hoe and we goin' get our hair did.
by DJ Van May 03, 2010