When a woman you're trying to get with delivers the fatal blow, signifying her interest only to be "friends" with you. From this vicious blow there is no recovery. Once the "kiss of death" has been administered, one may as well give up on that woman.
Damn.... Adam was trying to hook up with this hottie, but just when he thought he was in, she gave him the kiss of death and now he's home jerkin' off!
When a couple in separate moving cars drives in close and kisses while the two cars speed on. An object approaching the cars, the couple will let go at the last possible minute as the cars swerve away.
Me and Katy are real daredevils! To prove it we drove on two sides of a street pole and preformed the kiss of death!
When smoking marijuana discreetly in a confined environment (i.e. dorm room, office cubicle, etc.) smoke is often exhaled through dryer sheets for decreased smell. Sometimes, when an especially good hit is taken, brown lip-marks can be seen on the dryer sheet. This looks disgusting, and is known as the "kiss of death".
Good job man, you left a real kiss of death there.