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1.
To make something more convoluted, disheveled, twisted, or shittier than it was before the 'kirk' up in question occurred. To fuck up royally.
Person 1: Wow, the Texas Rangers committed a huge Kirk up by moving Michael Young to DH.

Person 2: Yeah, no wonder they haven't won a world series yet.

Historian 1: Hitler did indeed Kirk up when he invaded Russia with blatant disregard for the Soviet-German non aggression pact of 1939.

Historian 2: Yup, you should never get involved in a land war in Asia
by Pike-a-licious April 13, 2011