Top Definition
To shoot someone in the head, causing massive trauma to the point that brain matter splatters on a windshield or other area of the compartment. Mostly found in video game circles such as GTA4.
"Oh man did you see that? Varriano just totally Kennedy-ed that dudes skull. Aww sick look at the brain matter its all over the f*cking windshield"
#brain matter #sniping #skull explosion #assassination. jfk #kennedy.
by Lockhart May 17, 2008
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