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1. An actor who portrayed Uncle Jesse on Full House from 1987-1995, he originally became famous from starring in a soap opera called general hospital, and was on a show recently called ER, and has also done some Broadway shows in the early 2000's.

2. The sexiest man alive, great personality and a sultry voice.
"Oh my god who is that hot guy on full house?"
"Oh that's uncle Jesse aka John stamos aka the sexiest man alive"
by Madison P April 29, 2015
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2
it is quite possible that john stamos is the coolest individual to walk the earth. he has it all, from sweet hair to good looks to tight pants. definitely the best character from full house, aka uncle jesse. the "epitomy of coolness", john stamos is the guy every girl wants to date. every guy wants him as their best friend. he knows whats hip, cool, and he teaches DJ, stephanie, and michelle every moral they've ever learned.
john stamos` ex-wifes name is rebecca. my name is rebecca. coincidence? i think not. marry me, john stamos.

john stamos is the hottest guy ever, next to brad pitt.

jeez, look at that guy`s hair. he looks exactly like john stamos. sweet.
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3
1. Uncle Jessie from Full House
2. Taking a poop, while masterbating, and eating a bowl of cereal. A variation of the Bob Saget.
I did a John Stamos after watching full house.
by L. Roman July 16, 2006
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4
A Vodka shot lit on fire for a good 3 seconds before dumping it in YooHoo (chocolate milk) and chugging it.
Margaritas are sour, and John Stamos are sweet.
by muffinmonk May 05, 2011
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5
when a male buts a nut in a womens hair and slicks it back like john stamos.
Wow, i gave brittany a very stylish john stamos.
by freddygotfingered October 06, 2009
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6
Male actor who once portrayed Uncle Jesse in full house. Got his start by starring in such Gay Porn films as CliffBanger and Back Door Gardeners III. Was also caught in connection with Rob Lowe's seduction of two under aged males.
"*Farts*....Mhmmmm....."
"Unlce Jesse?"
"(Breathes deep and reaches pervertedly for the little Olsen girl)"
"(Olsen girl screams)"
"YOU'RE GAY JOHN STAMOS!"
by AssMan99 August 19, 2006
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7
Having intercourse with twins, and upon ejaculating saying " Have mercy"
I'm pretty sure back in 1992 John stamos banged the olson twins and when he came on there faces he said "have mercy"
by Hou Saou February 26, 2014
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