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1.
1. Possibly the most extreme, blasphomous term to use when one is surprised and/or outraged in the english language.
2. Used as a term to say something random but incomprehensible for a few seconds to the person the term is directed to.
Situation 1:

Somone busts into a room with an AK-47 and shoots the person right next to you.

Your response: Jesus fucking Mary doggystyle Christ!

Situation 2:

Johnny: Sooooo...
Mike: hmm....
Chris: yeah...
Dalton: JESUS FUCKING MARY DOGGYSYLE CHRIST!
Johnny: wtf happened?
Mike: oh my stars
Chris: lollerpops
by MrDinkleberry November 20, 2005