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1.
The Irish/UK version of Jesus H. Christ in a Chicken Basket, this phrase is used in extreme situations of shock, surprise, annoyance, or disgust. The addition of a well placed f-bomb can, of course, up the ante considerably.
"Liverpool couldn't beat Sheffield United?! Ah, Jesus H. Christ on a Bike!!!"

Helpful chap in bathroom: "I say, it appears that your penis is dripping a rather greenish looking slime."
You: "What?! JESUS H. FUCKING CHRIST ON A BIKE!!"
by Gaz Edmunds September 06, 2006