Top Definition
An exclamation you say when someone you depended on totally screws something up or you're faced with something that obviously just f*cked up your plans.
My sister to her husband-

"Jesus Christ in a Box, Michael! I said get the Playtex Supers in cardboard Tampons!... grrr Damnit!..."
by Kizzle: The Konqueror March 04, 2009

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The Urban Dictionary Mug

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